Hispanic Status Moderates Effects of Cognitive Impairment Risk Factors Lead Investigator: Brad Taylor Institution : University of Florida E-Mail : brad.taylor@ufl.edu Proposal ID : 1193 Proposal Description: Aims: One major area of health disparities appears to be in dementia, where greater risk has been reported for persons of Hispanic origin than for non-Hispanic persons. The current study will investigate whether Hispanic status might moderate the effect of common risk factors in the prediction of cognitive impairment. Hypotheses: It is hypothesized that older age, ApoE4 positive status, fewer years of education, and Hispanic Status will be associated with higher odds of being classified as Demented rather than Cognitively Normal and MCI. We further hypothesize that Hispanic Status will be associated with higher odds of being classified as MCI rather than Cognitively Normal. It is hypothesized that Hispanic status will moderate the effects of age and ApoE4 status, such that in non-Hispanic elders, higher age will be associated with larger odds of being Demented rather than MCI and Cognitively normal and of being MCI rather than cognitively normal. It is hypothesized that ApoE4 positivity will be associated with lower odds of being demented rather than MCI and cognitively normal and of being MCI rather than cognitively normal in non-Hispanic elders. Methods: The current study will be a secondary analysis of baseline data from a subset of National Alzheimer?s Coordinating Center (NACC) participants. Included in these analyses will be 13,459 cognitively-diverse, white participants aged 60-109, 55.6 female, 5.8 Hispanic. In a multinomial regression, the dependent variable will be cognitive status (cognitively normal [CN], or mild cognitive impairment [MCI] dementia [DEM] was the reference group). Risk factor predictors will be sex, age, ApoE4 positivity, and education. The main effect of Hispanic status, and its interaction with these risk factors, will be examined.